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Modify Date: 2024-01-02 18:13:09

CVT 10216 Structure
CVT 10216 structure
Common Name CVT 10216
CAS Number 1005334-57-5 Molecular Weight 465.475
Density 1.5±0.1 g/cm3 Boiling Point 714.2±70.0 °C at 760 mmHg
Molecular Formula C24H19NO7S Melting Point N/A
MSDS Chinese USA Flash Point 385.8±35.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of CVT 10216


CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1].

 Names

Name 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid
Synonym More Synonyms

 CVT 10216 Biological Activity

Description CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1].
Related Catalog
Target

IC50: 29 nM (ALDH-2)[1]

In Vivo CVT-10216 (intraperitoneal?injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1]. CVT-10216 (intraperitoneal?injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1].
References

[1]. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 714.2±70.0 °C at 760 mmHg
Molecular Formula C24H19NO7S
Molecular Weight 465.475
Flash Point 385.8±35.7 °C
Exact Mass 465.088226
PSA 131.29000
LogP 3.55
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.676

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport

 Synonyms

Benzoic acid, 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]-
3-{[(3-{4-[(Methylsulfonyl)amino]phenyl}-4-oxo-4H-chromen-7-yl)oxy]methyl}benzoic acid
CVT-10216
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  • Shanghai Nianxing Industrial Co., Ltd
  • China
  • Product Name: CVT-10216
  • Price: Click To Check
  • Purity: 98.0%
  • Delivery: 10 Day
  • Contact: Yang
  • Email: sales@echemcloud.com




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Price: ¥3900/5?mg

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