CVT 10216 structure
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Common Name | CVT 10216 | ||
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CAS Number | 1005334-57-5 | Molecular Weight | 465.475 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 714.2±70.0 °C at 760 mmHg | |
Molecular Formula | C24H19NO7S | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 385.8±35.7 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of CVT 10216CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1]. |
Name | 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid |
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Synonym | More Synonyms |
Description | CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1]. |
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Related Catalog | |
Target |
IC50: 29 nM (ALDH-2)[1] |
In Vivo | CVT-10216 (intraperitoneal?injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1]. CVT-10216 (intraperitoneal?injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1]. |
References |
[1]. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61. |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 714.2±70.0 °C at 760 mmHg |
Molecular Formula | C24H19NO7S |
Molecular Weight | 465.475 |
Flash Point | 385.8±35.7 °C |
Exact Mass | 465.088226 |
PSA | 131.29000 |
LogP | 3.55 |
Vapour Pressure | 0.0±2.4 mmHg at 25°C |
Index of Refraction | 1.676 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Precautionary Statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
Benzoic acid, 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]- |
3-{[(3-{4-[(Methylsulfonyl)amino]phenyl}-4-oxo-4H-chromen-7-yl)oxy]methyl}benzoic acid |
CVT-10216 |