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  • Shanghai Nianxing Industrial Co., Ltd
  • China
  • Product Name: Tubulysin B
  • Price:
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Yang


星空app:205304-87-6

205304-87-6 structure
205304-87-6 structure
  • Name: Tubulysin B
  • Chemical Name: Tubulysin B
  • CAS Number: 205304-87-6
  • Molecular Formula: C42H63N5O10S
  • Molecular Weight: 830.042
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-07-05 21:40:02
  • Modify Date: 2024-01-08 17:45:03
  • Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Name Tubulysin B
Synonyms (2S,4R)-4-[({2-[(1R,3R)-1-Acetoxy-3-{[(butyryloxy)methyl](N-{[(2R)-1-methyl-2-piperidinyl]carbonyl}-L-isoleucyl)amino}-4-methylpentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid
Tubulysin B
Pentanoic acid, 4-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-5-(4-hydroxyphenyl)-2-methyl-, (2S,4R)-
Description Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
Related Catalog
In Vitro Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.
References

[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.

[2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

Density 1.2±0.1 g/cm3
Boiling Point 978.0±65.0 °C at 760 mmHg
Molecular Formula C42H63N5O10S
Molecular Weight 830.042
Flash Point 545.3±34.3 °C
Exact Mass 829.429565
LogP 5.78
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.552


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